quinolinic acid वाक्य
उदाहरण वाक्य
मोबाइल
- Within the brain, quinolinic acid is only produced by activated microglia and macrophages.
- When inflammation occurs, quinolinic acid is produced in excessive levels through the kynurenine pathway.
- Quinolinic acid has also been found in HAND patients brains.
- Microglia and macrophages produce the vast majority of quinolinic acid present in the body.
- In this way, quinolinic acid self-potentiates its own toxicity.
- A third abused child in the sample did not have elevated levels of quinolinic acid.
- Quinolinic acid is also the bioprecursor of NAD +.
- Researchers utilize quinolinic acid in order to study Huntington s disease in many model organisms.
- Similar to HIV patients, this increased quinolinic acid concentration correlates with cognitive and motor dysfunction.
- Quinolinic acid's neuroactive and excitatory properties are a result of NMDA receptor agonism in the brain.
- Quinolinic acid is a downstream product of the kynurenine pathway, which metabolizes the amino acid tryptophan.
- Quinolinic acid has a potent neurotoxic effect.
- COX-2 inhibitors, such as licofelone have also demonstrated protective properties against the neurotoxic effects of quinolinic acid.
- The quinolinic acid produced in microglia is then released and stimulates NMDA receptors resulting in excitatory neurotoxiticity.
- Neurological changes produced by quinolinic acid injections include altered levels of glutamate, GABA, and other amino acids.
- Norharmane suppresses the production of quinolinic acid, 3-hydroxykynurenine and nitric oxide synthase, thereby acting as a neuroprotectant.
- Quinolinic acid is a byproduct of the kynurenine pathway, which is responsible for catabolism of tryptophan in mammals.
- Levels of quinolinic acid in the CSF of AIDS-dementia can be up to twenty times higher than normal.
- This action is in opposition to the agonist quinolinic acid, another kynurenine, noted for its potential as a neurotoxin.
- Lesions in the pallidum can suppress effects of quinolinic acid in monkeys injected with quinolinic acid into their striatum.
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